Drug interactions
Amlodipine-olmesartan + Bisoprolol
Severity: Moderate
Amlodipine-olmesartan and Bisoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol combined with amlodipine and olmesartan produces additive blood pressure reduction and may cause bradycardia or symptomatic hypotension. A small additive rise in potassium is also possible.
What this interaction means in plain words
Amlodipine-olmesartan and Bisoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Bisoprolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from beta blockade, calcium channel blockade and angiotensin receptor blockade.
What to do
Monitor blood pressure, heart rate and serum potassium, especially at initiation and dose changes. Adjust doses if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Amlodipine-olmesartan with Bisoprolol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Bisoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol combined with amlodipine and olmesartan produces additive blood pressure reduction and may cause bradycardia or symptomatic hypotension. A small additive rise in potassium is also possible.
How serious is the interaction between Amlodipine-olmesartan and Bisoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium, especially at initiation and dose changes. Adjust doses if hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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