Drug interactions
Amlodipine-olmesartan + Bretylium
Severity: Moderate
Amlodipine-olmesartan and Bretylium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium can cause marked hypotension through adrenergic neuron blockade, and antihypertensives may worsen this. Patients may experience symptomatic or orthostatic hypotension.
What this interaction means in plain words
Amlodipine-olmesartan and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects: sympathetic blockade from bretylium plus vasodilation and angiotensin receptor blockade.
What to do
Monitor blood pressure continuously during bretylium use and reduce or hold antihypertensives if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Bretylium?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium can cause marked hypotension through adrenergic neuron blockade, and antihypertensives may worsen this. Patients may experience symptomatic or orthostatic hypotension.
How serious is the interaction between Amlodipine-olmesartan and Bretylium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during bretylium use and reduce or hold antihypertensives if hypotension develops.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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