Drug interactions
Amlodipine-olmesartan + Butabarbital
Severity: Moderate
Amlodipine-olmesartan and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a barbiturate that induces hepatic enzymes, including CYP3A4. This can lower amlodipine concentrations and weaken blood pressure control. The effect may appear gradually after a few weeks of barbiturate use and persist after stopping it.
What this interaction means in plain words
Amlodipine-olmesartan and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 increases amlodipine metabolism and lowers its exposure.
What to do
Monitor blood pressure after starting or stopping butabarbital and increase the amlodipine dose if needed. Reassess the dose when the barbiturate is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Butabarbital?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is a barbiturate that induces hepatic enzymes, including CYP3A4. This can lower amlodipine concentrations and weaken blood pressure control. The effect may appear gradually after a few weeks of barbiturate use and persist after stopping it.
How serious is the interaction between Amlodipine-olmesartan and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping butabarbital and increase the amlodipine dose if needed. Reassess the dose when the barbiturate is discontinued.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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