Drug interactions
Amlodipine-olmesartan + Butalbital
Severity: Minor
Amlodipine-olmesartan and Butalbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with enzyme-inducing properties that may increase CYP3A4-mediated clearance of amlodipine. Antihypertensive effect could be reduced, though with intermittent analgesic use the impact is probably small. Regular or frequent use is more likely to matter.
What this interaction means in plain words
Amlodipine-olmesartan and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated induction of CYP3A4 may increase amlodipine metabolism.
What to do
Check blood pressure if butalbital is used regularly and adjust amlodipine dosing if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Butalbital?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate with enzyme-inducing properties that may increase CYP3A4-mediated clearance of amlodipine. Antihypertensive effect could be reduced, though with intermittent analgesic use the impact is probably small. Regular or frequent use is more likely to matter.
How serious is the interaction between Amlodipine-olmesartan and Butalbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure if butalbital is used regularly and adjust amlodipine dosing if control worsens.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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