Drug interactions
Amlodipine-olmesartan + Calcium chloride
Severity: Moderate
Amlodipine-olmesartan and Calcium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium chloride can reverse the hemodynamic effects of calcium channel blockers and is used as an antidote in overdose. In a patient taking amlodipine, a calcium bolus may therefore reduce its blood pressure lowering effect. The interaction is relevant mainly with parenteral dosing.
What this interaction means in plain words
Amlodipine-olmesartan and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased extracellular calcium overcomes L-type calcium channel blockade, antagonizing amlodipine's vasodilation.
What to do
Monitor blood pressure and heart rate when giving IV calcium to patients on amlodipine, and expect a reduced antihypertensive effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Calcium chloride?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium chloride can reverse the hemodynamic effects of calcium channel blockers and is used as an antidote in overdose. In a patient taking amlodipine, a calcium bolus may therefore reduce its blood pressure lowering effect. The interaction is relevant mainly with parenteral dosing.
How serious is the interaction between Amlodipine-olmesartan and Calcium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when giving IV calcium to patients on amlodipine, and expect a reduced antihypertensive effect.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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