Drug interactions
Amlodipine-olmesartan + Carvedilol
Severity: Moderate
Amlodipine-olmesartan and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol has alpha and beta blocking activity and adds substantially to the hypotensive effect of amlodipine and olmesartan, with risk of dizziness, syncope and bradycardia. It may also modestly raise potassium alongside the ARB.
What this interaction means in plain words
Amlodipine-olmesartan and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Carvedilol belongs to Cardiovascular.
Why it happens
Additive vasodilation and antihypertensive effects through alpha/beta blockade, calcium channel blockade and angiotensin receptor blockade.
What to do
Monitor blood pressure, heart rate and potassium, titrating doses slowly. Reduce doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Amlodipine-olmesartan with Carvedilol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol has alpha and beta blocking activity and adds substantially to the hypotensive effect of amlodipine and olmesartan, with risk of dizziness, syncope and bradycardia. It may also modestly raise potassium alongside the ARB.
How serious is the interaction between Amlodipine-olmesartan and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium, titrating doses slowly. Reduce doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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