Drug interactions
Amlodipine-olmesartan + Cenobamate
Severity: Moderate
Amlodipine-olmesartan and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may reduce amlodipine concentrations, leading to weaker blood pressure control. The change is typically gradual after cenobamate titration.
What this interaction means in plain words
Amlodipine-olmesartan and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Cenobamate belongs to Central Nervous System.
Why it happens
Cenobamate induction of CYP3A4 increases amlodipine metabolism.
What to do
Monitor blood pressure and increase the amlodipine dose as needed during cenobamate therapy. Reassess the dose if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Amlodipine-olmesartan with Cenobamate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may reduce amlodipine concentrations, leading to weaker blood pressure control. The change is typically gradual after cenobamate titration.
How serious is the interaction between Amlodipine-olmesartan and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase the amlodipine dose as needed during cenobamate therapy. Reassess the dose if cenobamate is stopped.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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