Drug interactions
Amlodipine-olmesartan + Conivaptan
Severity: Moderate
Amlodipine-olmesartan and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and can increase amlodipine exposure, leading to hypotension, flushing and peripheral edema. Conivaptan itself is also used in hypervolemic or euvolemic hyponatremia, where blood pressure shifts matter.
What this interaction means in plain words
Amlodipine-olmesartan and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, reducing amlodipine metabolism.
What to do
Monitor blood pressure and heart rate during conivaptan infusion. Reduce the amlodipine dose or hold it if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Conivaptan?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and can increase amlodipine exposure, leading to hypotension, flushing and peripheral edema. Conivaptan itself is also used in hypervolemic or euvolemic hyponatremia, where blood pressure shifts matter.
How serious is the interaction between Amlodipine-olmesartan and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during conivaptan infusion. Reduce the amlodipine dose or hold it if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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