Drug interactions
Amlodipine-olmesartan + Cyclopenthiazide
Severity: Minor
Amlodipine-olmesartan and Cyclopenthiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The thiazide diuretic adds antihypertensive effect to olmesartan and amlodipine. Thiazide-induced potassium loss is partly offset by the ARB, but hypotension and electrolyte disturbances remain possible.
What this interaction means in plain words
Amlodipine-olmesartan and Cyclopenthiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure lowering, with thiazide kaliuresis opposed by ARB-mediated potassium retention.
What to do
Monitor blood pressure, serum potassium and sodium, and renal function after initiation or dose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Cyclopenthiazide?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Cyclopenthiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The thiazide diuretic adds antihypertensive effect to olmesartan and amlodipine. Thiazide-induced potassium loss is partly offset by the ARB, but hypotension and electrolyte disturbances remain possible.
How serious is the interaction between Amlodipine-olmesartan and Cyclopenthiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and sodium, and renal function after initiation or dose changes.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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