Drug interactions
Amlodipine-olmesartan + Doxazosin
Severity: Moderate
Amlodipine-olmesartan and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxazosin adds to the blood pressure lowering effect of amlodipine and olmesartan. This can cause symptomatic hypotension, dizziness and syncope, particularly after the first dose or dose increases.
What this interaction means in plain words
Amlodipine-olmesartan and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Doxazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic vasodilation through alpha-1 blockade, calcium channel blockade and angiotensin receptor blockade.
What to do
Start doxazosin at a low dose, preferably at bedtime, and titrate while monitoring standing and sitting blood pressure. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Doxazosin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxazosin adds to the blood pressure lowering effect of amlodipine and olmesartan. This can cause symptomatic hypotension, dizziness and syncope, particularly after the first dose or dose increases.
How serious is the interaction between Amlodipine-olmesartan and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start doxazosin at a low dose, preferably at bedtime, and titrate while monitoring standing and sitting blood pressure. Advise patients to rise slowly.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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