Drug interactions
Amlodipine-olmesartan + Encorafenib
Severity: Moderate
Amlodipine-olmesartan and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can both inhibit and induce CYP3A4, so amlodipine exposure may be increased or reduced unpredictably. It may also inhibit OATP transporters, possibly raising olmesartan levels. The net clinical effect is uncertain.
What this interaction means in plain words
Amlodipine-olmesartan and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Encorafenib belongs to Oncology.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib affects amlodipine, and OATP1B1/1B3 inhibition may increase olmesartan exposure.
What to do
Monitor blood pressure and for signs of hypotension or loss of control, and adjust antihypertensive doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Amlodipine-olmesartan with Encorafenib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can both inhibit and induce CYP3A4, so amlodipine exposure may be increased or reduced unpredictably. It may also inhibit OATP transporters, possibly raising olmesartan levels. The net clinical effect is uncertain.
How serious is the interaction between Amlodipine-olmesartan and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for signs of hypotension or loss of control, and adjust antihypertensive doses accordingly.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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