Drug interactions
Amlodipine-olmesartan + Erythromycin ethylsuccinate
Severity: Moderate
Amlodipine-olmesartan and Erythromycin ethylsuccinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin ethylsuccinate is metabolized to active erythromycin, which inhibits CYP3A4 and can raise amlodipine levels. Hypotension and edema may result, particularly in older adults.
What this interaction means in plain words
Amlodipine-olmesartan and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4, decreasing amlodipine clearance.
What to do
Monitor blood pressure during the antibiotic course and consider a lower amlodipine dose or a non-interacting antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Erythromycin ethylsuccinate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin ethylsuccinate is metabolized to active erythromycin, which inhibits CYP3A4 and can raise amlodipine levels. Hypotension and edema may result, particularly in older adults.
How serious is the interaction between Amlodipine-olmesartan and Erythromycin ethylsuccinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during the antibiotic course and consider a lower amlodipine dose or a non-interacting antibiotic.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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