Drug interactions
Amlodipine-olmesartan + Fosamprenavir
Severity: Moderate
Amlodipine-olmesartan and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (as amprenavir) inhibits CYP3A4, which can increase amlodipine concentrations. Hypotension and edema may occur, and the effect is greater when the drug is boosted with ritonavir.
What this interaction means in plain words
Amlodipine-olmesartan and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by amprenavir, the active metabolite of fosamprenavir.
What to do
Monitor blood pressure and edema, and reduce the amlodipine dose if needed when starting or stopping fosamprenavir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Fosamprenavir?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir (as amprenavir) inhibits CYP3A4, which can increase amlodipine concentrations. Hypotension and edema may occur, and the effect is greater when the drug is boosted with ritonavir.
How serious is the interaction between Amlodipine-olmesartan and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and reduce the amlodipine dose if needed when starting or stopping fosamprenavir.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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