Drug interactions
Amlodipine-olmesartan + Glecaprevir / pibrentasvir
Severity: Minor
Amlodipine-olmesartan and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit OATP1B1/1B3 and other transporters, which may increase olmesartan exposure. The effect is expected to be modest, with possible additional hypotension or renal effects.
What this interaction means in plain words
Amlodipine-olmesartan and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake transport reduces olmesartan hepatic clearance.
What to do
No empirical dose change is generally required. Monitor blood pressure and renal function during hepatitis C therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit OATP1B1/1B3 and other transporters, which may increase olmesartan exposure. The effect is expected to be modest, with possible additional hypotension or renal effects.
How serious is the interaction between Amlodipine-olmesartan and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is generally required. Monitor blood pressure and renal function during hepatitis C therapy.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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