Drug interactions
Amlodipine-olmesartan + Grapefruit
Severity: Minor
Amlodipine-olmesartan and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and may slightly raise amlodipine exposure. The increase is modest and seldom clinically important.
What this interaction means in plain words
Amlodipine-olmesartan and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Furanocoumarins in grapefruit inhibit intestinal CYP3A4 and reduce first-pass metabolism of amlodipine.
What to do
Usually no action is needed; advise against large daily amounts and monitor for hypotension or edema.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Grapefruit?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and may slightly raise amlodipine exposure. The increase is modest and seldom clinically important.
How serious is the interaction between Amlodipine-olmesartan and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no action is needed; advise against large daily amounts and monitor for hypotension or edema.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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