Drug interactions
Amlodipine-olmesartan + Heparin
Severity: Moderate
Amlodipine-olmesartan and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin suppresses aldosterone secretion, and with olmesartan it can lead to hyperkalemia. The risk is higher with renal impairment, diabetes, and heparin use lasting several days.
What this interaction means in plain words
Amlodipine-olmesartan and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Heparin inhibits adrenal aldosterone synthesis, adding to ARB-mediated reduction in renal potassium excretion.
What to do
Monitor serum potassium in patients on prolonged heparin therapy or with renal impairment, and treat hyperkalemia if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Heparin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin suppresses aldosterone secretion, and with olmesartan it can lead to hyperkalemia. The risk is higher with renal impairment, diabetes, and heparin use lasting several days.
How serious is the interaction between Amlodipine-olmesartan and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on prolonged heparin therapy or with renal impairment, and treat hyperkalemia if it develops.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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