Drug interactions
Amlodipine-olmesartan + Hydrocortisone
Severity: Minor
Amlodipine-olmesartan and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone may slightly induce CYP3A4, but the effect on amlodipine is minimal. Its mineralocorticoid activity can cause fluid retention and raise blood pressure, opposing antihypertensive therapy.
What this interaction means in plain words
Amlodipine-olmesartan and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Weak CYP3A4 induction plus sodium and water retention from mineralocorticoid effects.
What to do
Monitor blood pressure and fluid status during sustained hydrocortisone use and adjust antihypertensives if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Hydrocortisone?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone may slightly induce CYP3A4, but the effect on amlodipine is minimal. Its mineralocorticoid activity can cause fluid retention and raise blood pressure, opposing antihypertensive therapy.
How serious is the interaction between Amlodipine-olmesartan and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and fluid status during sustained hydrocortisone use and adjust antihypertensives if needed.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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