Drug interactions
Amlodipine-olmesartan + Indapamide
Severity: Minor
Amlodipine-olmesartan and Indapamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide adds to the blood pressure lowering effect of olmesartan and amlodipine, and volume depletion may increase the risk of hypotension and renal function decline. Potassium effects oppose each other, so net change is variable.
What this interaction means in plain words
Amlodipine-olmesartan and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with diuretic volume depletion enhancing ARB hemodynamic effects.
What to do
Monitor blood pressure, serum potassium, sodium and creatinine after initiation or dose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Indapamide
Frequently asked questions
Can I take Amlodipine-olmesartan with Indapamide?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide adds to the blood pressure lowering effect of olmesartan and amlodipine, and volume depletion may increase the risk of hypotension and renal function decline. Potassium effects oppose each other, so net change is variable.
How serious is the interaction between Amlodipine-olmesartan and Indapamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium, sodium and creatinine after initiation or dose changes.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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