Drug interactions
Amlodipine-olmesartan + Insulin aspart protamine / insulin aspart
Severity: Moderate
Amlodipine-olmesartan and Insulin aspart protamine / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may enhance insulin sensitivity and in some patients increase the glucose-lowering effect of insulin. This can occasionally result in hypoglycemia, particularly when treatment is started.
What this interaction means in plain words
Amlodipine-olmesartan and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Angiotensin receptor blockade may improve insulin sensitivity, adding to insulin glucose-lowering; the mechanism is not fully established.
What to do
Monitor blood glucose more frequently when olmesartan is started or changed, and adjust the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may enhance insulin sensitivity and in some patients increase the glucose-lowering effect of insulin. This can occasionally result in hypoglycemia, particularly when treatment is started.
How serious is the interaction between Amlodipine-olmesartan and Insulin aspart protamine / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when olmesartan is started or changed, and adjust the insulin dose if hypoglycemia occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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