Drug interactions
Amlodipine-olmesartan + Insulin detemir
Severity: Minor
Amlodipine-olmesartan and Insulin detemir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may modestly improve insulin sensitivity, which can lower blood glucose in patients on insulin. This may increase the frequency of hypoglycemia, especially when the ARB is started or the dose is raised.
What this interaction means in plain words
Amlodipine-olmesartan and Insulin detemir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Insulin detemir belongs to Endocrine.
Why it happens
Possible improvement in insulin sensitivity by angiotensin II receptor blockade; the mechanism is not firmly established.
What to do
Monitor blood glucose more frequently when olmesartan is started or changed, and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Insulin detemir
Frequently asked questions
Can I take Amlodipine-olmesartan with Insulin detemir?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Insulin detemir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may modestly improve insulin sensitivity, which can lower blood glucose in patients on insulin. This may increase the frequency of hypoglycemia, especially when the ARB is started or the dose is raised.
How serious is the interaction between Amlodipine-olmesartan and Insulin detemir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when olmesartan is started or changed, and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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