Drug interactions
Amlodipine-olmesartan + Lithium
Severity: Major
Amlodipine-olmesartan and Lithium: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers such as olmesartan can raise serum lithium concentrations and have been associated with lithium toxicity. Signs include tremor, confusion, ataxia, vomiting and, in severe cases, seizures or arrhythmias.
What this interaction means in plain words
Amlodipine-olmesartan and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan belongs to Cardiovascular; Lithium belongs to Central Nervous System.
Why it happens
Reduced renal sodium and lithium clearance with increased proximal tubular lithium reabsorption due to angiotensin II blockade.
What to do
If coadministration is needed, check lithium levels at baseline and within the first week after starting or changing the dose, and reduce the lithium dose as needed. Educate the patient about toxicity symptoms and monitor renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan and Lithium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Lithium?
MediHelp rates the interaction as major. Amlodipine-olmesartan and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Angiotensin receptor blockers such as olmesartan can raise serum lithium concentrations and have been associated with lithium toxicity. Signs include tremor, confusion, ataxia, vomiting and, in severe cases, seizures or arrhythmias.
How serious is the interaction between Amlodipine-olmesartan and Lithium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is needed, check lithium levels at baseline and within the first week after starting or changing the dose, and reduce the lithium dose as needed. Educate the patient about toxicity symptoms and monitor renal function.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
