Drug interactions
Amlodipine-olmesartan + Nirmatrelvir
Severity: Moderate
Amlodipine-olmesartan and Nirmatrelvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirmatrelvir is given with ritonavir, which strongly inhibits CYP3A4 and raises amlodipine levels. This increases the risk of hypotension, edema and dizziness.
What this interaction means in plain words
Amlodipine-olmesartan and Nirmatrelvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Nirmatrelvir belongs to Anti Virals.
Why it happens
Ritonavir-boosted CYP3A4 inhibition reduces amlodipine clearance.
What to do
Consider reducing the amlodipine dose during the course and for a few days afterward, and monitor blood pressure and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Nirmatrelvir
- Alfuzosin + Nirmatrelvir Contraindicated
- Amiodarone + Nirmatrelvir Contraindicated
- Apalutamide + Nirmatrelvir Contraindicated
- Carbamazepine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Dronedarone + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Nirmatrelvir?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Nirmatrelvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nirmatrelvir is given with ritonavir, which strongly inhibits CYP3A4 and raises amlodipine levels. This increases the risk of hypotension, edema and dizziness.
How serious is the interaction between Amlodipine-olmesartan and Nirmatrelvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the amlodipine dose during the course and for a few days afterward, and monitor blood pressure and edema.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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