Drug interactions
Amlodipine-olmesartan + Nitroglycerin rectal
Severity: Moderate
Amlodipine-olmesartan and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrates combined with calcium channel blockers and ARBs produce additive vasodilation. Orthostatic hypotension, dizziness and syncope can occur.
What this interaction means in plain words
Amlodipine-olmesartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through nitric oxide-mediated venodilation plus calcium channel and angiotensin receptor blockade.
What to do
Monitor blood pressure, especially when starting or increasing nitroglycerin. Counsel patients to change position slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates combined with calcium channel blockers and ARBs produce additive vasodilation. Orthostatic hypotension, dizziness and syncope can occur.
How serious is the interaction between Amlodipine-olmesartan and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially when starting or increasing nitroglycerin. Counsel patients to change position slowly.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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