Drug interactions
Amlodipine-olmesartan + Nitroglycerin sublingual
Severity: Moderate
Amlodipine-olmesartan and Nitroglycerin sublingual: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both amlodipine and nitroglycerin dilate blood vessels, and olmesartan adds further blood pressure lowering. Together they can cause marked orthostatic hypotension, dizziness or syncope.
What this interaction means in plain words
Amlodipine-olmesartan and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure lowering.
What to do
Advise patients to sit when taking sublingual nitroglycerin and rise slowly, and monitor blood pressure. Reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Nitroglycerin sublingual?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both amlodipine and nitroglycerin dilate blood vessels, and olmesartan adds further blood pressure lowering. Together they can cause marked orthostatic hypotension, dizziness or syncope.
How serious is the interaction between Amlodipine-olmesartan and Nitroglycerin sublingual?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to sit when taking sublingual nitroglycerin and rise slowly, and monitor blood pressure. Reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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