Drug interactions
Amlodipine-olmesartan + Nitroprusside
Severity: Moderate
Amlodipine-olmesartan and Nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroprusside is a potent intravenous vasodilator, and background amlodipine and olmesartan can enhance its hypotensive effect. The infusion rate needed may be lower than expected.
What this interaction means in plain words
Amlodipine-olmesartan and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure lowering.
What to do
Titrate nitroprusside carefully with continuous blood pressure monitoring. Use lower starting infusion rates in patients taking these antihypertensives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Nitroprusside?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroprusside is a potent intravenous vasodilator, and background amlodipine and olmesartan can enhance its hypotensive effect. The infusion rate needed may be lower than expected.
How serious is the interaction between Amlodipine-olmesartan and Nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate nitroprusside carefully with continuous blood pressure monitoring. Use lower starting infusion rates in patients taking these antihypertensives.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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