Drug interactions
Amlodipine-olmesartan + Parecoxib
Severity: Moderate
Amlodipine-olmesartan and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, which is converted to valdecoxib, is an NSAID that can reduce the antihypertensive effect of olmesartan. It can also impair renal function and raise potassium, particularly in older or volume-depleted patients.
What this interaction means in plain words
Amlodipine-olmesartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and counters ARB effects.
What to do
Use the shortest NSAID course and keep patients hydrated. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Parecoxib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, which is converted to valdecoxib, is an NSAID that can reduce the antihypertensive effect of olmesartan. It can also impair renal function and raise potassium, particularly in older or volume-depleted patients.
How serious is the interaction between Amlodipine-olmesartan and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest NSAID course and keep patients hydrated. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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