Drug interactions
Amlodipine-olmesartan + Phenobarbital
Severity: Moderate
Amlodipine-olmesartan and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP3A4 and can lower amlodipine exposure. Blood pressure control may worsen during long-term phenobarbital use.
What this interaction means in plain words
Amlodipine-olmesartan and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction of CYP3A4 increases amlodipine metabolism.
What to do
Monitor blood pressure after phenobarbital is started or stopped. Adjust the amlodipine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Phenobarbital?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces CYP3A4 and can lower amlodipine exposure. Blood pressure control may worsen during long-term phenobarbital use.
How serious is the interaction between Amlodipine-olmesartan and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after phenobarbital is started or stopped. Adjust the amlodipine dose accordingly.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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