Drug interactions
Amlodipine-olmesartan + Rapacuronium
Severity: Moderate
Amlodipine-olmesartan and Rapacuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can enhance neuromuscular blockade from nondepolarizing agents, which may prolong paralysis. Rapacuronium is no longer widely marketed.
What this interaction means in plain words
Amlodipine-olmesartan and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium channel blockade reduces prejunctional acetylcholine release, adding to neuromuscular blockade.
What to do
Monitor neuromuscular function with a nerve stimulator and titrate the blocker to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Rapacuronium?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers can enhance neuromuscular blockade from nondepolarizing agents, which may prolong paralysis. Rapacuronium is no longer widely marketed.
How serious is the interaction between Amlodipine-olmesartan and Rapacuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and titrate the blocker to effect.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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