Drug interactions
Amlodipine-olmesartan + Rifampin
Severity: Moderate
Amlodipine-olmesartan and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces CYP3A4 and can markedly lower amlodipine concentrations, leading to loss of blood pressure control. Olmesartan is not meaningfully metabolized by CYP enzymes, so the effect mainly concerns the amlodipine component.
What this interaction means in plain words
Amlodipine-olmesartan and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic and intestinal CYP3A4 by rifampin increases amlodipine clearance.
What to do
Monitor blood pressure when rifampin is started or stopped and increase the antihypertensive dose or add another agent if control is lost. Reassess the dose after rifampin is discontinued because amlodipine levels will rise again.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Rifampin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin strongly induces CYP3A4 and can markedly lower amlodipine concentrations, leading to loss of blood pressure control. Olmesartan is not meaningfully metabolized by CYP enzymes, so the effect mainly concerns the amlodipine component.
How serious is the interaction between Amlodipine-olmesartan and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when rifampin is started or stopped and increase the antihypertensive dose or add another agent if control is lost. Reassess the dose after rifampin is discontinued because amlodipine levels will rise again.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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