Drug interactions
Amlodipine-olmesartan + Sacubitril / valsartan
Severity: Major
Amlodipine-olmesartan and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two angiotensin receptor blockers gives dual RAAS blockade without added benefit. It increases the risk of hypotension, hyperkalemia and renal dysfunction.
What this interaction means in plain words
Amlodipine-olmesartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate angiotensin II receptor blockade with additive effects on blood pressure, aldosterone suppression and renal function.
What to do
Avoid using olmesartan with sacubitril/valsartan and use a single ARB-containing regimen. If the switch is made, stop olmesartan and monitor potassium, creatinine and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Sacubitril / valsartan?
MediHelp rates the interaction as major. Amlodipine-olmesartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two angiotensin receptor blockers gives dual RAAS blockade without added benefit. It increases the risk of hypotension, hyperkalemia and renal dysfunction.
How serious is the interaction between Amlodipine-olmesartan and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using olmesartan with sacubitril/valsartan and use a single ARB-containing regimen. If the switch is made, stop olmesartan and monitor potassium, creatinine and blood pressure.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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