Drug interactions
Amlodipine-olmesartan + Salicylates
Severity: Minor
Amlodipine-olmesartan and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, but at higher doses they can still reduce the blood pressure effect of olmesartan and impair renal function. Potassium may rise through combined effects on renal function.
What this interaction means in plain words
Amlodipine-olmesartan and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced renal prostaglandin synthesis may blunt antihypertensive action and reduce glomerular filtration in combination with angiotensin receptor blockade.
What to do
No routine change is needed at low doses; check renal function and potassium if high-dose salicylates are used long term, especially in elderly or volume-depleted patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Salicylates?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, but at higher doses they can still reduce the blood pressure effect of olmesartan and impair renal function. Potassium may rise through combined effects on renal function.
How serious is the interaction between Amlodipine-olmesartan and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed at low doses; check renal function and potassium if high-dose salicylates are used long term, especially in elderly or volume-depleted patients.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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