Drug interactions
Amlodipine-olmesartan + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Amlodipine-olmesartan and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations can cause fluid loss and electrolyte shifts, and in combination with an angiotensin receptor blocker this raises the risk of hypotension and acute kidney injury. Hypermagnesemia may add to calcium channel blocker effects such as hypotension and weakness.
What this interaction means in plain words
Amlodipine-olmesartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion and electrolyte disturbance from the laxative combine with additive vasodilation and reduced renal autoregulation from olmesartan.
What to do
Ensure adequate hydration during bowel preparation and consider withholding olmesartan on the day of the preparation in patients at risk. Check renal function and electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations can cause fluid loss and electrolyte shifts, and in combination with an angiotensin receptor blocker this raises the risk of hypotension and acute kidney injury. Hypermagnesemia may add to calcium channel blocker effects such as hypotension and weakness.
How serious is the interaction between Amlodipine-olmesartan and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration during bowel preparation and consider withholding olmesartan on the day of the preparation in patients at risk. Check renal function and electrolytes in high-risk patients.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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