Drug interactions
Amlodipine-olmesartan + Sofosbuvir / velpatasvir
Severity: Minor
Amlodipine-olmesartan and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits intestinal and hepatic OATP transporters, which may increase olmesartan exposure. This could enhance blood pressure lowering and adverse effects.
What this interaction means in plain words
Amlodipine-olmesartan and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Velpatasvir inhibition of OATP1B1/1B3/2B1 reduces olmesartan uptake and clearance.
What to do
Monitor blood pressure and renal function after starting the hepatitis C regimen and reduce the olmesartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits intestinal and hepatic OATP transporters, which may increase olmesartan exposure. This could enhance blood pressure lowering and adverse effects.
How serious is the interaction between Amlodipine-olmesartan and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function after starting the hepatitis C regimen and reduce the olmesartan dose if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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