Drug interactions
Amlodipine-olmesartan + St john's wort
Severity: Moderate
Amlodipine-olmesartan and St john's wort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
St John's wort induces CYP3A4 and P-glycoprotein and can lower amlodipine concentrations, which may weaken blood pressure control. The effect is variable and depends on the preparation and duration of use.
What this interaction means in plain words
Amlodipine-olmesartan and St john's wort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by hyperforin increases the metabolism of amlodipine.
What to do
Avoid the combination where possible, or monitor blood pressure closely. Re-check blood pressure and consider increasing the antihypertensive dose if control is lost, and re-assess after the herbal product is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with St john's wort?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and St john's wort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. St John's wort induces CYP3A4 and P-glycoprotein and can lower amlodipine concentrations, which may weaken blood pressure control. The effect is variable and depends on the preparation and duration of use.
How serious is the interaction between Amlodipine-olmesartan and St john's wort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor blood pressure closely. Re-check blood pressure and consider increasing the antihypertensive dose if control is lost, and re-assess after the herbal product is stopped.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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