Drug interactions
Amlodipine-olmesartan + Synthetic human angiotensin ii
Severity: Moderate
Amlodipine-olmesartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan blocks the AT1 receptor and so opposes the pressor effect of exogenous angiotensin II. In patients with vasodilatory shock, prior ARB therapy may reduce the response to angiotensin II infusion and require higher doses.
What this interaction means in plain words
Amlodipine-olmesartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive AT1 receptor antagonism by olmesartan opposes angiotensin II.
What to do
Titrate angiotensin II to blood pressure response and expect higher dose requirements in patients recently taking olmesartan. Hold olmesartan in critically ill patients with hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan blocks the AT1 receptor and so opposes the pressor effect of exogenous angiotensin II. In patients with vasodilatory shock, prior ARB therapy may reduce the response to angiotensin II infusion and require higher doses.
How serious is the interaction between Amlodipine-olmesartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II to blood pressure response and expect higher dose requirements in patients recently taking olmesartan. Hold olmesartan in critically ill patients with hypotension.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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