Drug interactions
Ammonium chloride + Dextroamphetamine
Severity: Moderate
Ammonium chloride and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ammonium chloride acidifies urine, which increases the renal excretion of amphetamines as they are weak bases. This can lower dextroamphetamine plasma levels and shorten its duration of action, reducing effectiveness.
What this interaction means in plain words
Ammonium chloride and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Urinary acidification increases ionization of amphetamine and enhances its renal elimination.
What to do
Monitor for loss of clinical effect and adjust the dextroamphetamine dose if needed. Be aware that stopping the acidifier may raise amphetamine levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Ammonium chloride with Dextroamphetamine?
MediHelp rates the interaction as moderate. Ammonium chloride and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ammonium chloride acidifies urine, which increases the renal excretion of amphetamines as they are weak bases. This can lower dextroamphetamine plasma levels and shorten its duration of action, reducing effectiveness.
How serious is the interaction between Ammonium chloride and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of clinical effect and adjust the dextroamphetamine dose if needed. Be aware that stopping the acidifier may raise amphetamine levels.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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