Drug interactions
Amoxapine + Buprenorphine
Severity: Moderate
Amoxapine and Buprenorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and amoxapine also adds CNS depressant effects. Combined use may raise the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Amoxapine and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation through cardiac potassium channel effects, with additive CNS depression.
What to do
Obtain a baseline ECG and monitor QTc, and correct potassium and magnesium. Consider an alternative antidepressant if QTc lengthens substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Amoxapine with Buprenorphine?
MediHelp rates the interaction as moderate. Amoxapine and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and amoxapine also adds CNS depressant effects. Combined use may raise the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Amoxapine and Buprenorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, and correct potassium and magnesium. Consider an alternative antidepressant if QTc lengthens substantially.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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