Drug interactions
Amoxapine + Butorphanol
Severity: Moderate
Amoxapine and Butorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so combined use may deepen sedation and impair psychomotor function. Amoxapine's anticholinergic and hypotensive effects may add to the burden in older patients.
What this interaction means in plain words
Amoxapine and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid receptor agonism and antihistaminic and anticholinergic effects of the antidepressant.
What to do
Use reduced butorphanol doses and titrate carefully. Monitor sedation, blood pressure and respiratory rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Amoxapine with Butorphanol?
MediHelp rates the interaction as moderate. Amoxapine and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so combined use may deepen sedation and impair psychomotor function. Amoxapine's anticholinergic and hypotensive effects may add to the burden in older patients.
How serious is the interaction between Amoxapine and Butorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced butorphanol doses and titrate carefully. Monitor sedation, blood pressure and respiratory rate.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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