Drug interactions
Amoxapine + Chlordiazepoxide
Severity: Moderate
Amoxapine and Chlordiazepoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant with antipsychotic-like properties; with chlordiazepoxide it can increase drowsiness and psychomotor impairment. Amoxapine also lowers seizure threshold, which is relevant during benzodiazepine withdrawal.
What this interaction means in plain words
Amoxapine and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and antihistaminic and anticholinergic effects of amoxapine.
What to do
Monitor sedation and psychomotor function and start at low doses; warn patients against driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Amoxapine with Chlordiazepoxide?
MediHelp rates the interaction as moderate. Amoxapine and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant with antipsychotic-like properties; with chlordiazepoxide it can increase drowsiness and psychomotor impairment. Amoxapine also lowers seizure threshold, which is relevant during benzodiazepine withdrawal.
How serious is the interaction between Amoxapine and Chlordiazepoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and psychomotor function and start at low doses; warn patients against driving until response is known.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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