Drug interactions
Amoxapine + Citalopram
Severity: Major
Amoxapine and Citalopram: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining citalopram with amoxapine increases the risk of serotonin syndrome and of QT prolongation. Citalopram may also modestly raise levels of tricyclic-type antidepressants.
What this interaction means in plain words
Amoxapine and Citalopram can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects and additive QT prolongation, with possible CYP2D6-related increase in amoxapine exposure.
What to do
Avoid using together where possible. If necessary, use low doses, monitor ECG and watch for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Amoxapine with Citalopram?
MediHelp rates the interaction as major. Amoxapine and Citalopram can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining citalopram with amoxapine increases the risk of serotonin syndrome and of QT prolongation. Citalopram may also modestly raise levels of tricyclic-type antidepressants.
How serious is the interaction between Amoxapine and Citalopram?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using together where possible. If necessary, use low doses, monitor ECG and watch for serotonin toxicity.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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