Drug interactions
Amoxapine + Clemastine
Severity: Moderate
Amoxapine and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sedative and anticholinergic properties, so combining them can increase drowsiness, dry mouth, urinary retention, constipation and blurred vision. Older adults and patients with glaucoma or prostatic hypertrophy are at greater risk.
What this interaction means in plain words
Amoxapine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive anticholinergic effects from H1-antagonism and tricyclic activity.
What to do
Monitor for excessive sedation and anticholinergic toxicity, and counsel patients to avoid driving. Consider a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Amoxapine with Clemastine?
MediHelp rates the interaction as moderate. Amoxapine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sedative and anticholinergic properties, so combining them can increase drowsiness, dry mouth, urinary retention, constipation and blurred vision. Older adults and patients with glaucoma or prostatic hypertrophy are at greater risk.
How serious is the interaction between Amoxapine and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and anticholinergic toxicity, and counsel patients to avoid driving. Consider a non-sedating antihistamine if one is needed.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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