Drug interactions
Amoxapine + Darifenacin
Severity: Moderate
Amoxapine and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has anticholinergic activity and adds to darifenacin's antimuscarinic effects, risking constipation, urinary retention, dry mouth, blurred vision and confusion. Amoxapine is also metabolized partly by CYP2D6, which darifenacin inhibits weakly.
What this interaction means in plain words
Amoxapine and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic antagonism, with possible modest CYP2D6 inhibition by darifenacin.
What to do
Monitor for anticholinergic toxicity and antidepressant adverse effects, and consider an alternative with less anticholinergic activity in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Amoxapine with Darifenacin?
MediHelp rates the interaction as moderate. Amoxapine and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine has anticholinergic activity and adds to darifenacin's antimuscarinic effects, risking constipation, urinary retention, dry mouth, blurred vision and confusion. Amoxapine is also metabolized partly by CYP2D6, which darifenacin inhibits weakly.
How serious is the interaction between Amoxapine and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and antidepressant adverse effects, and consider an alternative with less anticholinergic activity in older patients.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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