Drug interactions
Amoxapine + Esketamine
Severity: Moderate
Amoxapine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating tricyclic-related antidepressant and can add to the drowsiness and dizziness from esketamine. Both drugs can also raise blood pressure or heart rate, which adds a cardiovascular consideration.
What this interaction means in plain words
Amoxapine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and possible additive sympathomimetic effects.
What to do
Monitor sedation and blood pressure before and after each esketamine session. Adjust amoxapine dosing if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Amoxapine with Esketamine?
MediHelp rates the interaction as moderate. Amoxapine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating tricyclic-related antidepressant and can add to the drowsiness and dizziness from esketamine. Both drugs can also raise blood pressure or heart rate, which adds a cardiovascular consideration.
How serious is the interaction between Amoxapine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure before and after each esketamine session. Adjust amoxapine dosing if excessive sedation occurs.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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