Drug interactions
Amoxapine + Ethinyl estradiol-levonorgestrel
Severity: Minor
Amoxapine and Ethinyl estradiol-levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined oral contraceptives may raise tricyclic antidepressant exposure and could alter antidepressant response. Patients may notice more anticholinergic, sedative or cardiovascular adverse effects. The effect is variable and usually modest.
What this interaction means in plain words
Amoxapine and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogens may inhibit hepatic oxidative metabolism of tricyclic antidepressants, although the mechanism is not firmly established.
What to do
Monitor for tricyclic adverse effects such as sedation, dry mouth and tachycardia, and for loss of antidepressant response when starting or stopping the contraceptive. Reduce the amoxapine dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Amoxapine with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as minor. Amoxapine and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combined oral contraceptives may raise tricyclic antidepressant exposure and could alter antidepressant response. Patients may notice more anticholinergic, sedative or cardiovascular adverse effects. The effect is variable and usually modest.
How serious is the interaction between Amoxapine and Ethinyl estradiol-levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects such as sedation, dry mouth and tachycardia, and for loss of antidepressant response when starting or stopping the contraceptive. Reduce the amoxapine dose if toxicity appears.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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