Drug interactions
Amoxapine + Ketamine
Severity: Moderate
Amoxapine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant and adds to ketamine CNS effects. Both can influence blood pressure and heart rate, and amoxapine may lower seizure threshold.
What this interaction means in plain words
Amoxapine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and sympathetic effects from noradrenaline reuptake inhibition.
What to do
Monitor sedation, heart rate and blood pressure, and use the lowest effective ketamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Amoxapine with Ketamine?
MediHelp rates the interaction as moderate. Amoxapine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant and adds to ketamine CNS effects. Both can influence blood pressure and heart rate, and amoxapine may lower seizure threshold.
How serious is the interaction between Amoxapine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, heart rate and blood pressure, and use the lowest effective ketamine dose.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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