Drug interactions
Amoxapine + Zolpidem
Severity: Moderate
Amoxapine and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, so combining them can increase drowsiness, impair psychomotor performance and cause confusion. Older patients are at greater risk of falls.
What this interaction means in plain words
Amoxapine and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and sedating antihistaminic and anticholinergic properties of amoxapine.
What to do
Use the lowest effective zolpidem dose and counsel on sedation and driving. Monitor for excessive sedation, particularly in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Frequently asked questions
Can I take Amoxapine with Zolpidem?
MediHelp rates the interaction as moderate. Amoxapine and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, so combining them can increase drowsiness, impair psychomotor performance and cause confusion. Older patients are at greater risk of falls.
How serious is the interaction between Amoxapine and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zolpidem dose and counsel on sedation and driving. Monitor for excessive sedation, particularly in older adults.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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