Drug interactions
Amphetamine polistirex + Esketamine
Severity: Moderate
Amphetamine polistirex and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise blood pressure and heart rate. Used together, hypertensive responses and cardiovascular strain may be amplified.
What this interaction means in plain words
Amphetamine polistirex and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic pressor and chronotropic effects.
What to do
Measure blood pressure before and about 40 minutes after each esketamine dose and monitor until stable. Defer esketamine if baseline blood pressure is markedly elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Frequently asked questions
Can I take Amphetamine polistirex with Esketamine?
MediHelp rates the interaction as moderate. Amphetamine polistirex and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise blood pressure and heart rate. Used together, hypertensive responses and cardiovascular strain may be amplified.
How serious is the interaction between Amphetamine polistirex and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure blood pressure before and about 40 minutes after each esketamine dose and monitor until stable. Defer esketamine if baseline blood pressure is markedly elevated.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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