Drug interactions
Amphetamine polistirex + Safinamide
Severity: Contraindicated
Amphetamine polistirex and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines with an MAO inhibitor risk hypertensive crisis and serotonin syndrome. Safinamide labeling contraindicates concomitant use with sympathomimetic stimulants.
What this interaction means in plain words
Amphetamine polistirex and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Amphetamine releases monoamines and inhibits their reuptake while MAO-B inhibition lessens their metabolism, causing additive effects.
What to do
Do not co-administer; use a non-stimulant treatment when safinamide is needed. Observe a washout interval after stopping either drug.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
Frequently asked questions
Can I take Amphetamine polistirex with Safinamide?
MediHelp rates the interaction as contraindicated. Amphetamine polistirex and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amphetamines with an MAO inhibitor risk hypertensive crisis and serotonin syndrome. Safinamide labeling contraindicates concomitant use with sympathomimetic stimulants.
How serious is the interaction between Amphetamine polistirex and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-stimulant treatment when safinamide is needed. Observe a washout interval after stopping either drug.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Clomipramine. The full list is on the Safinamide page.
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