Drug interactions
Amphotericin b cholesteryl + Captopril
Severity: Moderate
Amphotericin b cholesteryl and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established direct interaction exists, although amphotericin B can cause nephrotoxicity and hypokalemia while captopril affects renal hemodynamics and potassium. Combined use may worsen renal function in volume-depleted patients.
What this interaction means in plain words
Amphotericin b cholesteryl and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal effects from amphotericin-related nephrotoxicity and ACE inhibitor reduction of glomerular filtration pressure.
What to do
Monitor serum creatinine, potassium and blood pressure during combined therapy and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Amphotericin b cholesteryl with Captopril?
MediHelp rates the interaction as moderate. Amphotericin b cholesteryl and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. No well-established direct interaction exists, although amphotericin B can cause nephrotoxicity and hypokalemia while captopril affects renal hemodynamics and potassium. Combined use may worsen renal function in volume-depleted patients.
How serious is the interaction between Amphotericin b cholesteryl and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and blood pressure during combined therapy and ensure adequate hydration.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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