Drug interactions
Amphotericin b cholesteryl + Tenofovir disoproxil
Severity: Moderate
Amphotericin b cholesteryl and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can injure the kidneys, and combined use may worsen renal function. Reduced renal function in turn increases tenofovir exposure and the risk of tubular toxicity.
What this interaction means in plain words
Amphotericin b cholesteryl and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with reduced renal clearance of tenofovir as kidney function declines.
What to do
Monitor serum creatinine, phosphate and electrolytes regularly during combined therapy. Consider an alternative to tenofovir disoproxil, such as tenofovir alafenamide, if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Amphotericin b cholesteryl with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Amphotericin b cholesteryl and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can injure the kidneys, and combined use may worsen renal function. Reduced renal function in turn increases tenofovir exposure and the risk of tubular toxicity.
How serious is the interaction between Amphotericin b cholesteryl and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and electrolytes regularly during combined therapy. Consider an alternative to tenofovir disoproxil, such as tenofovir alafenamide, if renal function deteriorates.
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